Table 1.

Parameters and values used in extracellular drug transport and uptake.

Parameter	Symbol	Value	Reference
Free DOX diff. coefficient	kd	0.568 mm[2]/hr	[2]
Bound DOX diff. coefficient	kdb	0.032 mm[2]/hr	[2]
Rate of transmembrane transport	V1, V2 (V1 = V2)	0.28 ng/(105 cells)/min	[4]
Michaelis constant for transmembrane transport	k1	0.219 μg/ml	[4]
Michaelis constant for transmembrane transport	k2	1.37 ng/(105 cells)	[4]
Free DOX-albumin binding rate	k3	3000 hr-1	[2]
DOX-albumin dissociation rate	k4	1000 hr-1	[2]
Initial tumour cell density	Ct,0	106 cells/mm3	[2]
Tumour cell growth rate	a1	0.5 day-1	Estimated
Saturation constant in logistic equation	b	0.02592 mm3/(105 cells)/day	Estimated
Tumour cell natural decay rate	a2	0.24 day-1	Estimated
Tumour capillary radius	RC	10 μm	[2]
Tumour cord radius	RT	120 μm	[2]

Doxorubicin (DOX) is chosen as the anti-cancer drug for parameterization purpose.