Table 3. Prognostic factors of overall (OS) and disease-free (DFS) survival in sentinel node-staged CM patients (n = 1909). Results of multivariate Cox proportional hazard analysis.

	OS#			DFS##
Prognostic factor	RR	95% CI	p value	RR	95% CI	p value
Tumor thickness			<0.001			<0.001
≤1.0 mm	1			1
1.01–2.0 mm	1.6	0.69, 3.8		2.1	1.1, 3.8
2.01–4.0 mm	3.1	1.3, 7.2		3.8	2.0, 7.2
>4.0 mm	5.2	2.1, 12.7		5.7	3.0, 11.1
Ulceration *			<0.001			<0.001
Absent	1			1
Present	2.1	1.5, 3.0		2.2	1.7, 2.9
Body site			<0.001			<0.001
Upper limb	1			1
Head and Neck	3.8	1.7, 8.3		3.1	1.9, 5.0
Lower limb	2.5	1.3, 4.9		2.4	1.6, 3.6
Trunk	4.9	2.5, 9.6		2.9	1.9, 4.3
SLNB status			<0.001			<0.001
Negative	1			1
Positive	2.3	1.6, 3.1		2.3	1.8, 3.0
Histological subtype**			= 0.034			= 0.014
SSM	1			1
NM	1.1	0.73, 1.5		0.82	0.63, 1.1
LMM	0.72	0.20, 2.5		0.56	0.26, 1.2
ALM	2.2	1.3, 3.7		1.3	0.91, 1.9
Other	0.64	0.29, 1.4		0.54	0.32, 0.91
Gender			= 0.422			= 0.639
Age			= 0.166			= 0.133
Clark's level			= 0.823			= 0.747

RR = hazard ratio; 95% CI = 95% confidence interval.

*Adjusted for 304 missing values; Adjusted for 90 missing values;

^#Model for melanoma-specific survival was adjusted for the confounding effects of age and gender;

^##Model for disease-free survival was adjusted for the confounding effect of age.