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. 2012 Jan 19;7(1):e30342. doi: 10.1371/journal.pone.0030342

Table 2. Cytotoxic activities of deoxytylophorinine and its derivatives in vitro.

IC50 a(µM)
Compd HCT8 U251 HepG2 A549 A2780 BGC823 Capan2
f >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ##
g >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ##
h >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ##
i >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ##
j >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ## >10**, ##
1 0.31±0.19 0.34±0.14 0.13±0.10 0.14±0.08 0.27±0.20 1.17±1.17 0.34±0.19
2 1.54±0.86 1.34±0.77 1.08±0.70 1.74±1.08 2.82±0.23**, ## 8.54±2.53*, ## 1.90±1.22
3 0.29±0.13 0.89±0.63 0.75±0.57 4.77±2.85* >10**, ## 9.31±1.19**, ## 8.92±1.87**, ##
4 2.25±1.48 1.42±0.97 0.79±0.21**, # 1.27±0.74 5.52±4.00 7.79±2.19**, ## 0.61±0.30
5 0.42±0.08 1.73±1.00 1.19±1.15 2.71±1.52*,# 9.27±0.63**, ## 7.30±4.67 >10**, ##
6 0.22±0.17 0.38±0.15 0.26±0.14 0.27±0.08 0.19±0.14 0.42±0.05 0.92±0.75
7 0.25±0.11 0.41±0.17 0.22±0.03 0.42±0.18 >10**, ## 0.59±0.19 0.69±0.20
8 4.29±0.85**, ## 3.14±1.51*, # 3.25±0.77**, ## 4.57±1.26**, ## 8.05±1.99**, ## 9.49±0.55**, ## 6.70±3.02*, #
9 0.05±0.01# 0.07±0.05* 0.15±0.16 0.07±0.03 0.08±0.02# 0.08±0.03 0.19±0.21
10 0.45±0.08 0.70±0.33# 0.44±0.17 2.65±1.52* 8.82±2.04**, ## 6.58±3.79 2.79±0.99*
11 3.09±0.98**, # 4.69±1.96*, # 0.98±0.56 2.09±1.15*, # 7.59±2.50**, ## 6.77±3.39# 1.99±1.48
12 1.85±1.21 2.36±1.74 2.52±1.13*, # 4.98±1.80**, # 3.93±0.94**, ## 6.88±2.94*, # 4.03±1.97*
13 5.59±0.32**, ## 3.35±0.97**, ## 4.00±0.41**, ## 4.84±1.18**, ## 8.87±1.96**, ## 9.85±0.26**, ## 6.67±0.54**, ##
14 3.17±1.62* 3.56±1.19**, ## 3.09±0.85**, ## 4.52±1.94*, # 8.31±2.55**, ## 7.44±2.55*, # 6.30±1.24**, #
15 7.77±3.86*, # 6.38±3.16*, # 9.03±1.69**, ## 7.61±2.38**, ## >10**, ## >10**, ## 9.14±1.50**, ##
16 5.35±1.60**, ## 2.77±1.59# 3.02±0.92**, ## 3.71±0.72**, ## 8.72±2.21**, ## 7.29±3.35*, # 3.13±1.16*
17 5.57±1.05**, ## 3.17±0.79**, ## 3.87±0.63**, ## 4.91±0.84**, ## 6.81±2.62*, # 9.38±1.08**, ## 4.07±1.26**
18 2.93±1.47* 2.13±1.02*, # 2.40±0.76**, ## 2.83±1.39*, # 5.51±3.32 5.07±4.27 9.02±1.03**, ##
19 7.06±1.72**, ## 5.14±0.90**, ## 4.10±0.79**, ## 5.27±1.21**, ## 9.20±1.39**, ## 9.50±0.86**, ## 6.36±3.33*
20 4.72±0.36**, ## 4.02±0.31**. ## 4.88±1.64**, ## 4.26±1.03**, ## 6.66±1.02**, ## 7.95±1.79**, ## 5.81±2.43*
21 4.95±0.40**, ## 3.24±0.74**, ## 4.27±1.17**, ## 4.06±1.33**, ## 4.77±0.92**, ## 8.26±1.77**, ## 5.08±1.49**, #
22 3.01±0.97**, # 2.63±0.63**, ## 2.45±0.62**, ## 3.34±0.73**, ## 3.33±0.83**, ## 4.55±2.78 3.67±2.85
23 7.69±2.01**, ## 8.20±1.05**, ## 5.09±0.75**, ## 7.33±3.42*, # >10**, ## 9.31±1.19**, ## 6.30±3.25*
24 4.17±1.30**, ## 3.51±1.83*, # 2.34±1.39 3.18±1.57*, # 6.67±3.06*, # 7.60±2.14*, ## 4.10±1.30**
25 5.68±0.97**, ## 3.30±0.69**, ## 2.85±0.35**, ## 3.91±0.40**, ## 5.21±1.08**, ## 7.77±2.13**, ## 6.44±1.26**, #
26 5.86±2.31*, # 5.61±1.56**, ## 4.54±1.30**, ## 4.64±0.96**, ## 9.25±1.29**, ## >10**, ## 7.42±1.66**, #
27 5.74±1.08**, ## 4.62±1.34**, ## 3.77±1.31**, ## 6.32±3.44*, # 6.21±2.73*, # 8.51±1.30**, ## 8.02±3.42*, #
28 4.81±0.94**, ## 4.51±0.59**, ## 3.36±0.83**, ## 5.96±3.34*, ## 8.46±1.81**, # 7.46±2.61*, # 8.29±1.57**, ##
29 3.76±1.51*, # 3.23±0.79**, ## 3.45±1.38*, # 6.05±3.52*, # 4.61±0.16**, ## 7.42±2.66*, # 5.77±2.62*
30 4.58±0.75**, ## 3.82±1.28**, ## 3.48±1.16**, ## 4.92±1.84*, # 4.83±0.34**, ## 6.02±3.45 8.14±2.07**, #
31 5.97±1.25**, ## 3.76±0.30**, ## 3.40±0.27**, ## 5.90±3.43*, # 7.86±1.95**, ## 6.17±0.14**, ## 9.50±0.86**, ##
32 0.02±0.02# 0.05±0.01* 0.05±0.01 0.07±0.02 4.56±1.23**, ## 0.11±0.11 0.42±0.30
33 0.03±0.01# 0.04±0.01* 0.02±0.01 0.40±0.15 0.05±0.04,# 0.26±0.13 0.43±0.21
34 7.60±0.52**, ## 6.27±1.02**, ## 6.75±2.81*, # 6.94±2.72*, # 9.20±1.39**, ## >10**, ## 4.70±0.59**, #
35 3.97±1.03**, ## 3.89±0.00**, ## 5.78±3.67 4.61±1.15**, ## 6.69±3.43*, # 9.05±1.28**, ## 3.31±0.70**
Doxorubicin 0.61±0.25 0.13±0.09 0.23±0.25 0.23±0.16 0.63±0.27 0.97±0.92 1.57±1.45
a

IC50 values are the test compounds concentration (µM) that inhibited the cell growth by 50%. Data represent the mean values ± standard deviation of three dependent experiments performed in triplicate (*, p<0.05 compared with compound 1; **, p<0.01 compared with compound 1; #, p<0.05 compared with Doxorubicin; ##, p<0.01 compared with Doxorubicin). These IC50 values were all measured for 72 h treatment. IC50 values for 24 h treatment were in Table S1.