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. 2012 Jan 19;8(1):e1002464. doi: 10.1371/journal.pgen.1002464

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Hao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A schematic illustrating the ric-7 gene structure is shown. Deleted regions (bar), point mutations (arrows), and the site utilized for GFP/mCherry tagging are indicated. (B–C) Aldicarb-induced paralysis (B) and locomotion rate (C) are compared for the indicated genotypes. The number of trials (∼20 animals/trial, B) or the number of animals analyzed (C) are indicated for each genotype. For rescue experiments, ric-7 transgenes are indicated as follows: ACh (unc-17 promoter), GABA (unc-25 promoter), pan-neuron (snb-1 promoter), muscle (myo-3 promoter). Values that differ significantly from wild type (**, p<0.001, Student's t-test) and from ric-7 mutants (#, p<0.01; ##, p<0.001, Student's t-test) are indicated. Error bars indicate SEM.