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. 2012 Jan 19;8(1):e1002359. doi: 10.1371/journal.pcbi.1002359

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von Kleist et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Potential mechanisms for resistance development against AZT through increasing its excision rate via an ATP-mediated mechanism (see eq. (21)). We calculated residual DNA-dependent polymerization of a Poly-T sequence in unstimulated T-cells using eq. (19) with parameters from Tables 1, S1 and S3 (supplementary material). The solid black line shows residual DNA polymerization in the wild type virus, whereas the dotted red line and the dashed blue line refer to residual polymerization if and were decreased- and increased 100-fold respectively.

Inline graphic — Potential mechanisms for resistance development against AZT through increasing its excision rate via an ATP-mediated mechanism (see eq. (21)). We calculated residual DNA-dependent polymerization of a Poly-T sequence in unstimulated T-cells using eq. (19) with parameters from Tables 1, S1 and S3 (supplementary material). The solid black line shows residual DNA polymerization in the wild type virus, whereas the dotted red line and the dashed blue line refer to residual polymerization if and were decreased- and increased 100-fold respectively.