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. 2012 Jan 19;8(1):e1002359. doi: 10.1371/journal.pcbi.1002359

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von Kleist et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Dashed blue-, solid green- and dotted magenta line indicate the selective advantage of the Q151M, the multi-drug resistant Q151M-complex (Q151Mc: A62V/V75I/F77L/F116Y/Q151M) and the Q151Mc+K70Q mutation during DNA-dependent polymerization of a random sequence of length 500 with 25% respective dNTP content in unstimulated cells. The light grey area indicates the in vivo concentrations range of TFV-DP from [56], [71], [73], converted to units by assuming a cell volume of for resting T-cells [72]. The dashed horizontal line indicates the threshold for resistance selection, i.e. . Panel A: Selective advantage of the respective mutants with regard to wild type . B: Selective advantage of a succeeding mutants with regard to progenitor in Q151M complex formation . All utilized parameters are indicated in Table 1 and Tables S1, S2 (supplementary material).

Dashed blue-, solid green- and dotted magenta line indicate the selective advantage of the Q151M, the multi-drug resistant Q151M-complex (Q151Mc: A62V/V75I/F77L/F116Y/Q151M) and the Q151Mc+K70Q mutation during DNA-dependent polymerization of a random sequence of length 500 with 25% respective dNTP content in unstimulated cells. The light grey area indicates the in vivo concentrations range of TFV-DP from [56], [71], [73], converted to units by assuming a cell volume of for resting T-cells [72]. The dashed horizontal line indicates the threshold for resistance selection, i.e. . Panel A: Selective advantage of the respective mutants with regard to wild type . B: Selective advantage of a succeeding mutants with regard to progenitor in Q151M complex formation . All utilized parameters are indicated in Table 1 and Tables S1, S2 (supplementary material).