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. 2012 Jan 19;8(1):e1002359. doi: 10.1371/journal.pcbi.1002359

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von Kleist et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Solid blue-, green- and red line indicate epistasis with regard to replication , resistance and fitness as defined in eqs. (5)–(7) for the double mutant ‘K65R/M184V’. The black dashed horizontal line indicates the value, where no epistatic interactions occur. The light grey area indicates the in vivo concentrations range of TFV-DP from [56], [71], [73], converted to units by assuming a cell volume of for unstimulated T-cells [72]. All utilized parameters are indicated in Table 1 and Tables S1, S2 (supplementary material).

Inline graphic — Solid blue-, green- and red line indicate epistasis with regard to replication , resistance and fitness as defined in eqs. (5)–(7) for the double mutant ‘K65R/M184V’. The black dashed horizontal line indicates the value, where no epistatic interactions occur. The light grey area indicates the in vivo concentrations range of TFV-DP from [56], [71], [73], converted to units by assuming a cell volume of for unstimulated T-cells [72]. All utilized parameters are indicated in Table 1 and Tables S1, S2 (supplementary material).