Table 3. Cell-specific values of AZT-TP for ‘poly-thymidine’ polymerization and susceptibility change by resistance development.

	RNA/DNA			DNA/DNA
cell type	‘wt’	‘res’*	fold res.	‘wt’	‘res’*	fold res.
act.			4.5			4.1
rest.			15.7			22.6
macr.			17.2			22.5

values, expressed in , were calculated using eqs. (20)–(21). Cell-specific parameters were taken from Table 1. All kinetic parameters were taken from Table 1 and Tables S1, S2, S3 (supplementary material).

*‘res’ = D67N/K70R/T215Y/K219Q mutant.