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. 2011 Aug 22;120(1):62–67. doi: 10.1289/ehp.1103437

Figure 2.

Figure 2

Suppression of BT-induced apoptosis and ROS generation by ROS scavengers (catalase and methionine) and an MPO inhibitor (ABAH). (A) Percentages of apoptotic cells in HL-60 exposed to 50 μM BT for 8 hr in the presence of MPO inhibitor and ROS scavengers; data presented are mean +SE from four to six independent experiments conducted in duplicate. (B) Effects of catalase on ROS generated by BT, as shown by fluorescence intensity of HE (for O2•−), DCFH‑DA (for H2O2), APF (for HOCl), and HPF (for •OH) in cells exposed to BT or BT plus catalase for 30 min (mean + SE from three to five independent experiments conducted in duplicate). (C) Effects of ABAH on ROS generated by BT, as shown by fluorescence intensity of HE, APF, and HPF in cells exposed for 30 min to BT or BT plus ABAH (mean + SE from three to five independent experiments conducted in duplicate). *p < 0.05, and **p < 0.01 compared with the corresponding cells exposed to BT alone.