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. 2011 Sep 27;120(1):92–97. doi: 10.1289/ehp.1104061

Figure 5.

Figure 5

Inhibition of Akt decreases the expression of ZEB1 and ZEB2, and siRNA knockdown of ZEB1 and ZEB2 reduces As-transformed p53lowHBEC migration and invasion. (A) Inhibition of Akt but not Erk1/2 decreases the expression of ZEB1 and ZEB2. Wort., wortmannin. (B) siRNA knockdown of the expression of ZEB1 and ZEB2. (C) siRNA knockdown of ZEB1 and ZEB2 reduces As-transformed p53lowHBEC migration and invasion (means ± SDs, n = 3). Similar results were obtained in two additional experiments. *p < 0.05, compared with control siRNA-transfected cells.