Table 1.

Extra risk at the NOAEL and the SNCD, expressed as medians and lower 5th (P05) and upper 95th (P95) percentiles across the n data sets considered.

Point estimate of extra risk					UER
PoD	Casea	n	Median	P05	P95	Median	P05	P95
NOAEL		1		786		0.060		0.020		0.33		0.11		0.039		0.51
		1b		596		0.063		0.018		0.37		0.11		0.036		0.56
		1c		665		0.067		0.020		0.37		0.12		0.038		0.55
		1d		439		0.089		0.022		0.42		0.14		0.040		0.60
		2		133		0.061		0.022		0.43		0.11		0.038		0.63
		3		330		0.086		0.020		0.45		0.14		0.036		0.64
		4		456		0.055		0.022		0.17		0.096		0.040		0.28
SNCD1.0		1		439		0.11		0.026		0.44		0.18		0.038		0.63
		2		106		0.13		0.025		0.39		0.21		0.038		0.56
		3		217		0.19		0.028		0.50		0.30		0.040		0.73
		4		222		0.062		0.026		0.29		0.098		0.038		0.46
SNCD0.67		1		665		0.042		0.013		0.23		0.073		0.021		0.41
		2		124		0.045		0.013		0.25		0.083		0.021		0.41
		3		243		0.11		0.010		0.33		0.19		0.018		0.57
		4		422		0.029		0.013		0.12		0.047		0.022		0.23
aDifferent subsets of the 786 data sets were considered, as represented by the following cases. Case 1: All data sets adequate for dose–response modeling [according to the criteria in Supplemental Material, Section 1 (http://dx.doi.org/10.1289/ehp.1003327)] and for which an SNCD was derived; all 786 data sets adequate for modeling were included for the NOAEL case. Case 1b: Data sets in case 1 for which the NOAEL was lower than the highest dose. Case 1c: Data sets in case 1 for which an SNCD0.67 was derived. Case 1d: Data sets in case 1 for which an SNCD1.0 was derived. Case 2: Data sets with the lowest NOAEL in each selected technical report included in case 1. Case 3: Data sets in case 1 including at most one dose for which the observed extra risk was > 0 and ≤ 0.2; the observed extra risk at a given dose, i, was calculated as [xi/ni – p(0)]/[1 – p(0)], where p(0) is the point estimate of the background risk. Case 4: Data sets in case 1 including more than one dose for which the observed extra risk was > 0 and ≤ 0.2.