Table 1.

Chemical-independent model parameter baseline values.

Parameter	Valuea
Total quantity of CYP2E1 (mmol)	2.09 × 10–5b
Alveolar ventilation rate (mL/min)	62.5c
Cardiac output (mL/min)	62.5c
Fraction of cardiac output to compartments
Liver	0.25
Fat	0.09
Poorly perfused tissues	0.15
Richly perfused tissues	0.51d
Total body volume (mL)	250
Volume of compartments (mL)
Liver	10
Fat	17.5c
Richly perfused tissues	12.5
Poorly perfused tissues	185e
aData from U.S. Environmental Protection Agency (1988), except for CYP2E1 quantity. bData from Carlile et al. (1997) and Seaton et al. (1995). cSubsequently sampled from statistical distributions (see “Materials and Methods”), using the given values as means. dComputed as 1.0 minus the sum of the other cardiac output fractions. eComputed as 0.9 times total body volume minus the sum of the other tissue volumes.