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. 2011 Aug 3;119(12):1775–1780. doi: 10.1289/ehp.1103781

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Silencing of Gpr30 or Ers-1 inhibited BPA-induced cell proliferation (A, B) and fos gene expression (C, D) in GC-1 cells transfected with control scrambled (CS)-ODN and GPR30/AS-ODN (A, C) or with CS-ODN and Ers‑1/AS-ODN (B, D) and treated with E2 (10^–9 M), BPA (10^–9 M), G1, PPT, or DPN (each at 10^–7 M). Cell proliferation was determined by MTT assay (A, B), and fos mRNA levels were examined with real-time RT-PCR (C, D), as described in “Materials and Methods.” Values shown (mean ± SE) represent results of three independent experiments performed in triplicate; the control value was set as 1. *p < 0.05, compared with control. **p < 0.05, compared with E2. ^#p < 0.05, compared with BPA. ^##p < 0.05, compared with G1. ^†p < 0.05, compared with PPT.