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. 2012 Jan 19;8(1):e1002465. doi: 10.1371/journal.pgen.1002465

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Cheutin, Cavalli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A–C: Non-normal distribution of PC enrichment within PC bodies. 3D images of embryos expressing PH-GFP (A) or PC-GFP (B) show intense and faint PC bodies. The scale bar is 2 µm. Histogram showing the distribution of PC enrichment within PC bodies (C). D–H: The amount of PC within a PC body depends on the genomic length of regions bound by PC. 2D images of Immuno-FISH experiments performed with probes located in large (∼400 kb: ANT-C and ∼340 kb: BX-C), medium (∼200 kb: NK-C) or small (∼50 kb: hh, hth and svp) genomic regions coated by PC, as well as probes directed against beat-Vc which is not coated by PC (D). The scale bar is 2 µm. Cumulative histograms of PC enrichment measured within the FISH volumes (N>500 for each FISH probe) (E). 1-µm profiles of PC enrichment along lines crossing their corresponding FISH volumes (N>57 for each FISH probe) (F). Histograms showing that homologous chromosome pairing increases the enrichment of PC within PC bodies containing ANT-C (p<0.001, KS test with N>190) (G) or BX-C loci (p<0.001, KS test with N>175) (H).