Table 1. Working panel of proposed correlates of protection for the intracellular bacterium Francisella.

Mediator	Fold change (range) compared to naive*
	LVS	LVS-G	LVS-R	HK-LVS
Group 1:
IFN-γ	23.8 (13 – 359)	49 (12 – 347)	5.5 (0.8 – 33)	0.5 (0.2 – 1.2)
IL-6	6.8 (2.5 – 8)	4.1 (0.8 – 7)	0.8 (0.5 – 2)	0.5 (0.4 – 1.2)
IL-12rβ2	2.8 (1.6 – 4)	2.0 (1.2 – 5)	1.1 (0.7 – 1.8)	0.7 (0.5 – 1.1)
T-bet	3.0 (1.7 – 10)	3.0 (1.9 – 5)	1.5 (0.9 – 3)	1.0 (0.4 – 2)
IL-18bp	3.4 (3.1 – 7)	2.6 (0.7 – 6)	1.4 (1.3 – 1.7)	1.0 (0.4 – 1.7)
SOCS-1	4.1 (2.7 – 15)	7.0 (3 – 17)	3.6 (1.0 – 5)	1.2 (0.8 – 1.6)
Group 2:
GM-CSF	3.8 (0.4 – 10)	3.8 (1.5 – 12)	0.8 (0.4 – 2.3)	0.3 (0.3 – 1.7)
TNF-α	2.5 (1.4 – 3)	1.3 (0.8 – 4)	0.9 (0.7 – 1.8)	1.0 (0.8 – 1.1)
Irf-1	2.2 (1.5 – 4)	2.3 (1.3 – 5)	1.5 (1.8 – 3)	0.5 (0.5 – 1.64
IL-22	2.7 (0.4 – 14)	4.2 (1.1 – 13)	1.2 (0.4 – 3)	0.4 (0.1 – 1.2)
IL-27	4.4 (2.2 – 7)	3.3 (0.7 – 8)	1.0 (0.9 – 3)	1.1 (0.5 – 1.7)
CCL7 (MCP-3)	2.4 (1.9 – 2.6)	1.5 (0.3 – 1.9)	0.6 (0.5 – 0.7)	0.6 (0.3 – 2.0)

*The median fold change of the indicated mediator for each indicated vaccine group is shown, with the range across all experiments in parenthesis. For the range in parentheses, fold change values over 2 were rounded to the nearest whole number, and those less than 2 were rounded to one decimal place. Results from 4 total experiments were included (see Table S2). p values for logistic regressions of associations between degree of gene expression and degree of survival were all<0.001 (see Table S4).