TABLE 1.
BASELINE CHARACTERISTICS OF CHRONIC KIDNEY DISEASE CASES AND NONCASES
| Characteristic* | CKD (−) (n = 11,708) | CKD (+) (n = 204) | Difference† (95% CI) |
| Mean age, yr | 25.8 | 39.0 | 13.2 (11.3 to 15.1) |
| Male sex, yr | 53.2 | 45.6 | 7.6 (0.7 to 14.6) |
| Homozygous ΔF508, % | 48.7 | 48.2 | 0.5 (−7.2 to 8.3) |
| Mean BMI, kg/m2 | 21.4 | 20.9 | 0.5 (0 to 0.9) |
| Mean percent-predicted FEV1, % | 65.4 | 56.2 | 9.2 (6.1 to 12.3) |
| Greater than or equal to one acute pulmonary exacerbation, % | 40.6 | 33.3 | 7.2 (0.7 to 13.8) |
| CFRD requiring insulin, % | 13.3 | 33.3 | 20.0 (13.4 to 26.6) |
| Inhaled tobramycin use, % | 50.7 | 33.3 | 17.4 (10.8 to 24) |
| HD ibuprofen use, % | 3.7 | 2 | 1.7 (0.2 to 3.7) |
| Pseudomonas aeruginosa culture, % positive | 74.6 | 75.4 | 0.8 (−5.4 to 7) |
| Burkholderia cepacia culture, % positive | 4.4 | 3.1 | 1.2 (−1.3 to 3.7) |
Definition of abbreviations: BMI = body mass index; CFRD = cystic fibrosis–related diabetes; CI = confidence interval; CKD = chronic kidney disease; HD = high dose.
*
In the year before cohort entry.
†
Absolute difference with 95% CI.