TABLE 3.

FINAL MULTIVARIABLE COX PROPORTIONAL HAZARD MODEL

Exposure	CKD Hazard Ratio (95% CI)
Acute pulmonary exacerbations*
No exacerbations	REF
One to five exacerbations	0.79 (0.56–1.11)
Six to nine exacerbations	0.92 (0.58–1.46)
≥ 10 exacerbations	1.16 (0.75–1.81)
CFRD (insulin-requiring)*
0 yr	REF
1–4 yr	2.40 (1.74–3.32)
≥ 5 yr	4.56 (2.85–7.28)
Per additional year of age	1.11 (1.10–1.12)
Per additional year of inhaled tobramycin use	0.89 (0.81–0.97)
Per unit increase in BMI, kg/m2	0.86 (0.82–0.90)

Definition of abbreviations: BMI = body mass index; CFRD = cystic fibrosis–related diabetes; CI = confidence interval; CKD = chronic kidney disease.

^*Includes exposure up to 3 years before cohort entry.