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Effects of other CC chemokines on the MMP-3 gene expression and protein secretion in human chondrosarcoma cells. SW1353 cells were incubated with 1 ng/ml IL-1β, or various concentrations of RANTES (A) or MCP-1 (B) for 24 h. MMP-3 mRNA levels were analyzed by RT-PCR, and the protein expressed in cells (c.MMP-3) and secreted in media (m.MMP-3) were assayed by Western blotting. These experiments were performed three times.
