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Models of eotaxin-1 function on MMP-1 gene expression and protein secretion in human chondrocytes. (A) Eotaxin-1 binds G protein-coupled CCRs, such as CCR3, and induces MMP-3 expression through cAMP/PKA inhibition and MAP kinase activation. (B) Eotaxin-1 at low concentrations is able to promote MMP-3 release from the cells by activating PLC/PKC and MAP kinase pathways.
