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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: FEBS J. 2011 Dec 19;279(3):370–383. doi: 10.1111/j.1742-4658.2011.08430.x

Fig. 8. Schematic indicating identified nucleolin:Hdm2 domains interactions and its biological significance.

Fig. 8

Nucleolin-Hdm2 interactions by the RBD1–4 and NT domains of nucleolin presumably inhibit Hdm2-p53 interaction via its p53BD and central domain that contained the NLS/NES region. This antagonism results in decreased Hdm2-mediated p53-ubiquitination, stabilizing cellular p53 protein levels.