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Structures of monovalent and oligovalent amyloid-binding molecules. A) Cartoon depicting the monovalent (left) or oligovalent (right) binding of molecules to amyloid fibrils. B) Chemical structures of monovalent (1) and oligovalent (2–5) derivatives of benzothiazole aniline (BTA). A rudimentary estimate of the length (in fully extended conformation) of the flexible group attached to BTA was calculated using Chem-Bio3D Ultra 12.0 software.
