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(A) Immunostaining of hypoxia marker pimonidazole of representative tumors of control mice and pyruvate-treated mice (1 h and 5 h after [1-13C]pyruvate injection). (B) Pimonidazole positive area in control tumors (n = 5) and tumors 1 h after (n=5) and 5 h after (n=5) [1-13C]pyruvate injection.
