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Mapping phosphorylation by synthetic dosage lethality.
| Kinase | Substrate | Effect |
|---|---|---|
| + | + | No effect |
| − | + | No effect |
| + | − | No effect |
| − | − | Lethality |
Strains containing gain- or loss-of-function kinase mutations were screened for the suppression or exacerbation of phenotypes resulting from the overexpression or mutation of the candidate substrates. Thus, strains containing the mutated kinase or substrate alone were viable, but strains containing both the mutated kinase and substrate were not.
