Figure 1.

Linking skin and brain amyloidosis. Skin and brain are connected in several ways. Based on the published data describing the spread amyloid deposits, it is feasible that cutaneous amyloid spread to other organs including the brain (1) or vice versa (2). This strong connection between both organs makes it a viable and attractive option for the treatment several neurodegenerative amyloidosis via transdermal administration of therapeutics (3). The skin–brain connection not only involved amyloid treatment and formation, but also has an important relevance in several dermatologic conditions linked to neuroimmunological stress, in which an increase of neuropeptides in the skin (4) or the brain (5) has been reported.