Table 3.
Logistic regression of factors associated with at least one prescription of cholinesterase inhibitors in the incidence year and characteristics of ChEI users vs.non-users
| Characteristics | ChEI users (n = 241) |
Non-users (n = 1,607) |
Proportion of ChEI user (n = 1,848) |
Model 1a) ORcrude (95% CI) |
Model 2b) ORadj (95% CI) |
|---|---|---|---|---|---|
| Age groups, in years | |||||
| 65-74 | 107 (44.4%) | 459 (28.6%) | 18.9% | 3.32 (2.13-5.18) | 1.41 (0.85-2.34) |
| 75-84 | 107 (44.4%) | 763 (47.5%) | 12.3% | 2.00 (1.29-3.10) | 1.30 (0.81-2.11) |
| 85+ | 27 (11.2%) | 385 (24.0%) | 6.6% | 1 | 1 |
| Sex | |||||
| Male | 137 (56.8%) | 832 (51.8%) | 14.1% | 1.23 (0.93-1.61) | 0.89 (0.65-1.21) |
| Female | 104 (43.2%) | 775 (48.2%) | 11.8% | 1 | 1 |
| Area of residence* | |||||
| Urban | 168 (69.7%) | 1161 (72.3%) | 12.6% | 1 | 1 |
| Rural | 73 (30.3%) | 444 (27.7%) | 14.1% | 1.14 (0.85-1.53) | 1.48 (1.06-2.06) |
| Number of prescribed medications | |||||
| Q1 (0-6) | 90 (37.3%) | 520 (32.4%) | 14.8% | 1.43 (0.97-2.10) | 0.93 (0.58-1.49) |
| Q2 (7-9) | 59 (24.5%) | 352 (21.9%) | 14.4% | 1.38 (0.91-2.10) | 1.03 (0.64-1.65) |
| Q3 (10-13) | 48 (19.9%) | 372 (23.1%) | 11.4% | 1.06 (0.69-1.64) | 0.79 (0.49-1.28) |
| Q4 (14+) | 44 (18.3%) | 363 (22.6%) | 10.8% | 1 | 1 |
| Level of care dependency | |||||
| None | 161 (66.8%) | 866 (53.9%) | 15.7% | 5.83 (1.82-18.61) | 5.35 (1.61-17.81) |
| 1 | 41 (17.0%) | 341 (21.2%) | 10.7% | 3.77 (1.14-12.44) | 4.32 (1.26-14.75) |
| 2 | 36 (14.9%) | 306 (19.0%) | 10.5% | 3.69 (1.11-12.24) | 3.97 (1.16-13.60) |
| 3 | 3 (1.2%) | 94 (5.8%) | 3.1% | 1 | 1 |
| Symptom complexes characterizing geriatric patients | |||||
| 0 | 33 (13.7%) | 115 (7.2%) | 22.3% | 3.46 (1.87-6.41) | 4.23 (2.06-8.69) |
| 1-2 | 120 (49.8%) | 707 (44.0%) | 14.5% | 2.05 (1.22-3.44) | 2.52 (1.41-4.50) |
| 3-4 | 70 (29.0%) | 568 (35.3%) | 11.0% | 1.49 (0.87-2.55) | 1.59 (0.89-2.84) |
| 5+ | 18 (7.5%) | 217 (13.5%) | 7.7% | 1 | 1 |
| Contacts to neurologists/psychiatrists | |||||
| 0 | 43 (17.8%) | 981 (61.0%) | 4.2% | 1 | 1 |
| 1-2 | 16 (6.6%) | 151 (9.4%) | 9.6% | 2.42 (1.33-4.40) | 2.53 (1.37-4.65) |
| 3-5 | 44 (18.3%) | 137 (8.5%) | 24.3% | 7.33 (4.64-11.57) | 7.86 (4.88-12.66) |
| 6-9 | 84 (34.9%) | 141 (8.8%) | 37.3% | 13.59 (9.04-20.43) | 14.05 (9.14-21.59) |
| 10+ | 54 (22.4%) | 197 (12.3%) | 21.5% | 6.25 (4.07-9.60) | 7.66 (4.85-12.11) |
a) crude models
b) multivariate model adjusted for all other variables
* missing values for 2 patients for which classification into the urban or rural group was not possible