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. 2011 Sep 29;13(5):R95. doi: 10.1186/bcr3020

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Copyright ©2011 Stefansson et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of ploidy on DNA copy-number changes in BRCA2 breast tumors. (a) Event-frequency plots to compare the genomic regions affected in diploid (blue) and aneuploid (red) types of BRCA2 tumors. (b) The proportion of the genome altered in BRCA2 tumors with respect to ploidy. (c) Three example genomic profiles analyzed by aCGH to illustrate complex changes in BRCA2 tumors classified as diploid by flow-cytometry. The genomic profiles represent DNA copy-changes number toward gains (above) or losses (below) on the y-axis by chromosomal position on the x-axis from p- to q-arms, left to right, respectively.