Table 4.

Multivariate analysis of EFS according to standard parameters and the combined B-Cell/IL8-metagene in TNBC

		Finding cohort A*				Validation cohort C*
Variable		No. of patients†	Hazard ratio	95% CI	P-value‡	No. of patients§	Hazard ratio	95% CI	P-value‡
Lymph node status	LNN vs N1	210 vs 27	0.59	0.31 to 1.12	0.10	43 vs 29	0.40	0.17 to 0.99	0.046
Age	> 50 vs ≤ 50	113 vs 124	0.75	0.48 to 1.17	0.21	48 vs 24	1.68	0.65 to 4.38	0.29
Tumor size	≤ 2 cm vs > 2 cm	71 vs 166	0.73	0.44 to 1.21	0.22	11 vs 61	0.99	0.28 to 3.42	0.98
Histological grading	G3 vs G1 and 2	166 vs 71	1.11	0.68 to 1.81	0.68	59 vs 13	0.53	0.22 to 1.29	0.16
B-Cell/IL8-Signature	Good vs Poor||	78 vs 159	0.38	0.22 to 0.67	0.001	29 vs 43	0.21	0.07 to 0.62	0.005

* Results from multivariate Cox analysis of event free survival in the TNBC finding cohort A and validation cohort C are presented.

† information on all parameters was available for 237 of the 297 TNBC samples with follow up data from the finding cohort A.

‡ Significant P-values are given in bold

§ information on all parameters was available for 72 of the 76 TNBC samples with follow up data from the validation cohort C.

|| "Good" refers to high B-Cell metagene together with low IL8 metagene expression compared to all the remaining samples referred as "Poor".