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. 2011 Oct 24;13(5):R101. doi: 10.1186/bcr3042

Figure 4.

Figure 4

Quercetin dose-dependently inhibited self-renewal of human and mouse breast cancer cells. 2 × 104 cells/ml of AS-B145 (A), AS-B244 cells (B) or Sca-1+ 4T1(C) were subjected into primary (1st) mammosphere culture in present of quercetin (50, 25 or 12.5 μM) or 0.1% DMSO. For secondary mammosphere (2nd) cultivation, 1st spheres were collected, digested by accutase and 5,000 cells/ml were subjected into mammosphere cultivation in present of quercetin or DMSO. Data were collected at Day 7 after the start of cultivation and presented as a relative percentage of DMSO. Bar in (A), 100 μm; bar in (B), 50 μm; bar in (C), 200 μm. *, P < 0.05; #, P < 0.01.