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. 2011 Oct 26;13(5):R104. doi: 10.1186/bcr3046

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Copyright ©2011 Kotb et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cyst formation in Ncadk.i. and Ncadk.i.;p53 mammary glands. With increasing lactation cycles, the accumulation of fibrous tissue was accompanied by the formation of cysts. After ten lactation cycles, H&E-stained paraffin sections showed cyst formation in both Ncadk.i. and Ncadk.i.;p53 mammary glands, while no cysts were observed in controls. Premalignant marks, such as calcification (arrows) and accumulation of necrotic material (arrowheads), were detected in both lines. Cyst formation was accompanied by a downregulation of CFTR. Oil Red staining showed the accumulation of lipids in alveolar epithelial cells in Ncadki. and Ncadk.i;p53 mammary glands. Scale bar: 100 μm. CFTR, Cystic Fibrosis Transmembrane Conductance Regulator; H&E, Hematoxylin and Eosin; Ncadk.i., WAP::Cre;Ecad^Ncad/fl; Ncadk.i.;p53, WAP::Cre;Ecad^Ncad/fl;p53^fl/+.