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. 2012 Jan 3;2:90. doi: 10.3389/fgene.2011.00090

Table A6.

Rates of SNPs and indels that affect microRNAs and transcription factor binding sites (TFBS).

PG17 (all SNPs, %) PG26 (all SNPs, %) PG17 (all ins, %) PG26 (all ins, %) PG17 (all del, %) PG26 (all del, %)
miRNA
Total number of variants creating miRNA binding sites 0.19 0.19 0.12 0.13 0.16 0.16
Total number of variants destroying miRNA binding sites 0.19 0.19 0.18 0.17 0.12 0.10
Total number of variants perturbing miRNA binding sites (diff deltaG > 0) 0.43 0.42 0.52 0.50 0.48 0.48
TFB
Total number of TFBS disrupting variants 19.05 19.63 17.01 17.77 30.24 32.04
Total number of major TFBS disrupting variants (dScore < −7) 0.13 0.14 4.45 4.81 17.86 19.17
Total number of TFBS deleting variants 0.00 0.00 0.00 0.00 0.25 0.29

The functional annotation was done with the complementary genome-wide variant annotation tools embedded in a suite of tools developed by researchers at The Scripps Research Institute (see reference Torkamani et al., 2011).