Table A6.
Rates of SNPs and indels that affect microRNAs and transcription factor binding sites (TFBS).
| PG17 (all SNPs, %) | PG26 (all SNPs, %) | PG17 (all ins, %) | PG26 (all ins, %) | PG17 (all del, %) | PG26 (all del, %) | |
|---|---|---|---|---|---|---|
| miRNA | ||||||
| Total number of variants creating miRNA binding sites | 0.19 | 0.19 | 0.12 | 0.13 | 0.16 | 0.16 |
| Total number of variants destroying miRNA binding sites | 0.19 | 0.19 | 0.18 | 0.17 | 0.12 | 0.10 |
| Total number of variants perturbing miRNA binding sites (diff deltaG > 0) | 0.43 | 0.42 | 0.52 | 0.50 | 0.48 | 0.48 |
| TFB | ||||||
| Total number of TFBS disrupting variants | 19.05 | 19.63 | 17.01 | 17.77 | 30.24 | 32.04 |
| Total number of major TFBS disrupting variants (dScore < −7) | 0.13 | 0.14 | 4.45 | 4.81 | 17.86 | 19.17 |
| Total number of TFBS deleting variants | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.29 |
The functional annotation was done with the complementary genome-wide variant annotation tools embedded in a suite of tools developed by researchers at The Scripps Research Institute (see reference Torkamani et al., 2011).