Table 6.

Bupropion SR^Rx

Product	Zyban® (GlaxoSmithKline plc, Brentford, London, England, UK), Generic 150 mg sustained-release tablet
Contraindications	History of seizure disorder History of stroke History of brain tumor, brain surgery, or serious closed head injury Eating disorders Those taking another form of bupropion Monoamine oxidase inhibitor therapy within previous 14 d Abrupt discontinuation of alcohol or benzodiazepines at same time
Precautions	Pregnancy Concomitant therapy with medications known to lower the seizure threshold
Dosage	150 mg PO q AM × 3 d, then increase to 150 mg PO BID Treatment should be initiated while patient is still smoking Set quit date 1–2 weeks after initiation DO NOT exceed 300 mg/d Allow at least 8 h between doses Avoid bedtime dosing to minimize insomnia Can be used safely with NRT If progression towards abstinence unsuccessful by week 7, discontinue Duration: 8–12 wk, maintenance up to 6 months
Side effects	Insomnia most common (35%–40%) Dry mouth Nervousness Agitation Anxiety Weight loss Constipation Seizures (risk is 1/1000)
Advantages	Bupropion can be safely used with NRT Bupropion may be beneficial in patients with depression No tapering required
Disadvantages	Seizure risk is increased May increase the risk of suicidal thinking in patients who have depression