Supplementary Table 2.

Pharmacokinetic blood sample schedule in the ketoconazole study

Study day	Saxagliptin, 5-hydroxy saxagliptin Pharmacokinetic sampling time (hours)	Ketoconazole Pharmacokinetic sampling time (hours)a
1	0 (predose), 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 18
2	24, 36
3	48
6		0 (predose)
7		0 (predose)
8		0 (predose), 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 10, 12
9	0 (predose), 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 10, 12, 16, 20	0 (predose), 0.25, 0.5, 0.75, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7, 8, 10, 12
10	24, 36
11	48, 60
12	72

^aNote: Relative to morning dose of ketoconazole.