Table 4.

Rate of Treatment Adjustment (Number of Adjustments Over 12 Months)

Therapeutic Class	Rate (95% CI)		Relative Ratea (95% CI)
	Intervention	Usual Care
Antidepressant	3.37 (2.92–3.89)	0.53 (0.34–0.82)	6.20b (3.88–9.90)
Insulin	3.26 (2.43–4.36)	1.02 (0.67–1.55)	2.97b (1.83–4.83)
Oral hypoglycemic	0.62 (0.44–0.88)	0.34 (0.23–0.50)	1.80c (1.07–3.01)
Antihypertensive	2.33 (1.86–2.92)	1.11 (0.81–1.51)	1.86b (1.28–2.71)
Lipid lowering	0.81 (0.64–1.03)	0.55 (0.42–0.72)	1.56c (1.10–2.20)

Note: Treatment adjustment defined as (1) an increase in the number of medication classes prescribed, (2) a change in dosage of at least 1 ongoing medication class, (3) a switch to a medication in a different class, or (4) a switch to a different medication within the same class over the 12-month intervention period. Medication adjustment includes initiations and subsequent treatment changes.

^aAdjusted for baseline Poisson regressions with robust (Huber-White) standard errors predicting the rate of adjustments (baseline to 12 months) within each therapeutic class.

^bP value <.001.

^cP value <.05.