Table 5.
Adjusteda mean (95% confidence interval) blood pressure at baseline and change from baseline, separated for fixed dose and titration design studies (only marketed doses included)
| SBP | DBP | |||
|---|---|---|---|---|
|
|
|
|||
| Baseline | Change | Baseline | Change | |
| Fixed-dose design | ||||
| Enalapril 20 mg (n = 150) | 157.0 (154.2, 159.8) | −10.8 (−13.3, −8.3) | 100.5 (99.5, 101.6) | −9.3 (−10.8, −7.8) |
| Lisinopril 20 mg (n = 25) | 154.7 (149.0, 160.5) | −18.8 (−25.0, −12.6) | 96.7 (94.8, 98.5) | −11.0 (−14.7, −7.3) |
| Ramipril 10 mg (n = 927) | 155.3 (154.4, 156.1) | −9.3 (−10.7, −7.8) | 100.3 (100.0, 100.6) | −8.0 (−8.9, −7.2) |
| Ramipril 20 mg (n = 123) | 153.9 (151.7, 156.1) | −11.1 (13.9, −8.2) | 101.5 (100.8, 102.2) | −9.0 (−10.8, −7.3) |
| Telmisartan 40 mg (n = 112) | 155.1 (152.5, 157.8) | −13.2 (−16.1, −10.3) | 101.4 (100.6, 102.2) | −10.2 (−11.9, −8.4) |
| Telmisartan 80 mg (n = 1150) | 156.0 (155.2, 156.7) | −14.1 (−15.2, −12.9) | 100.3 (100.0, 100.6) | −10.8 (−11.5, −10.1) |
| Titration designb | ||||
| Enalapril 20 mg (n = 468) | 163.1 (161.8, 164.5) | −17.6 (−19.1, −16.1) | 98.9 (98.2, 99.6) | −12.1 (−13.1, −11.1) |
| Lisinopril 40 mg (n = 110) | 151.0 (148.3, 153.7) | −14.2 (−17.7, −10.8) | 99.9 (99.1, 100.8) | −7.4 (−9.5, −5.3) |
| Telmisartan 80 mg (n = 578) | 160.6 (159.4, 161.8) | −19.0 (−20.3, −17.7) | 99.5 (98.9, 100.0) | −13.0 (−13.8, −12.2) |
a
Notes: Adjusted for baseline and study;
b
maximum dose is given.
Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure.