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. 2012 Jan;46(1):55–62. doi: 10.1165/rcmb.2011-0169OC

Figure 1.

Figure 1.

The deletion of Fra-1 confers protection against LPS-induced mortality. (A and B) Kaplan-Meier survival curves of Fra-1–sufficient (Fra-1+/+) and Fra-1–deficient (Fra-1Δ/Δ) mice injected with intraperitoneal LPS (n = 10 for each genotype) at doses of 40 mg/kg (A) and 60 mg/kg (B) or vehicle PBS (n = 6 for each genotype). Survival of Fra-1Δ/Δ mice was significantly enhanced, compared with that of Fra-1+/+ mice, at both concentrations of LPS. Differences in mortality were assessed according to log-rank test (P < 0.05).