Skip to main content
. 2012 Jan;46(1):55–62. doi: 10.1165/rcmb.2011-0169OC

Figure 3.

Figure 3.

Effect of Fra-1 deficiency on intratracheal LPS-induced acute lung injury (ALI). Fra-1+/+ and Fra-1Δ/Δ mice were instilled with PBS (n = 4 for each genotype) or LPS (10 μg/ mouse) (n = 6 for each genotype) via the intratracheal route, and killed after 24 hours. Lung injury and inflammation were assessed. (A) Hematoxylin-and-eosin–stained images of lung histopathology in Fra-1+/+ and Fra-1Δ/Δ mice. Arrows indicate presence of neutrophils in the alveolar spaces. (B) Total protein and (C) total and inflammatory cells in the BAL fluid of Fra-1+/+ and Fra-1Δ/Δ mice treated with PBS or LPS for 24 hours. *P < 0.05, PBS versus LPS. †P < 0.05, Fra-1+/+ mice versus Fra-1Δ/Δ mice.