Figure 1.

(A) Ephrin-A1 increases lung vascular permeability in wild-type but not in EphA2-deficient animals, as measured by the filtration coefficient (Kf) in isolated, perfused murine lungs. *P < 0.01 versus all other groups; n = 4–5 animals per group. (B) Pulmonary vascular resistance (PVR) does not significantly change with ephrin-A1 perfusion in isolated, perfused murine lungs. wt/s, wild-type, buffer-perfused; wt/EFNA1, wild-type, ephrin-A1–perfused; KO/s, EphA2-knockout, buffer-perfused; KO/EFNA1, EphA2-knockout, ephrin-A1–perfused.