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ET-1 increases splicing of X-box binding protein 1 (XBP-1) in PASMCs. ET-1 activates the inositol requiring enzyme 1 (IRE-1)/XBP-1 arm of the UPR, as evidenced by a twofold increase in the spliced form of XBP-1 (sXBP-1), normalized to the housekeeping gene HPRT. This effect is inhibited by ETA antagonism (BQ123), and to a lesser extent, by ETB antagonism (BQ788). *P < 0.05, compared with DMSO. **P < 0.05, compared with ET-1–induced concentration of sXBP-1.
