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. 2012 Jan;46(1):63–70. doi: 10.1165/rcmb.2011-0147OC

Figure 3.

Figure 3.

Confocal imaging shows altered distribution of GSNO reductase in squamous-cell lung carcinoma cells. (A) GSNO reductase is localized in punctate cytoplasmic structures and in mitotic spindles in nonmalignant bronchoepithelial cells (CFBE41o−). (B) GSNO reductase colocalization with mitotic spindles is inhibited by colchicine. (C) GSNO reductase (red) is colocalized with wt Ras (green) in CFBE41o− cells, but not (F) in squamous-cell carcinoma cells (H226). (D) The localization of GSNO reductase is perinuclear in primary squamous-cell lung carcinoma cells. (E) Background fluorescence (negative control).