TABLE 4.

TOP HITS FROM GENE-BASED ASSOCIATION ANALYSIS FOR SPIROMETRIC GENOME-WIDE SIGNIFICANCE GENES AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE CANDIDATE GENES

SNP*	Genes	Ref. Allele†	Frequency‡	OR	P Value§
rs11134242	ADCY2	G	0.59–0.63	1.23	0.0001
rs10204348	TNS1	G	0.36–0.41	0.83	0.0002
rs4316710	THSD4	C	0.81–0.83	0.79	0.0003
rs4235415	FLJ20184/GSTCD/INTS12	G	0.13–0.17	0.77	0.0004
rs7724666	ADAM19	C	0.87–0.89	1.32	0.0006
rs4713505	AGER/PPT2	T	0.26–0.3	0.83	0.0008
rs17706683	HTR4	A	0.05–0.06	0.55	0.0009
rs645419	MMP1/MMP12	G	0.46–0.48	0.85	0.001
rs12206691	DAAM2	A	0.98–0.98	1.79	0.004
rs2736172	TNF	C	0.61–0.65	1.16	0.004
rs11933466	NPNT	A	0.2–0.25	0.84	0.005
rs17736515	SFTPB	A	0.05–0.07	1.38	0.005
rs3917386	IL1B	C	0.06–0.06	1.42	0.008
rs7580152	PID1	A	0.14–0.15	1.21	0.009
rs8176707	ABO	G	0.88–0.91	0.80	0.01
rs2853209	ADAM33	A	0.45–0.5	1.15	0.01
rs3744787	TIMP2	G	0.12–0.15	1.20	0.01
rs9389983	GPR126	T	0.48–0.54	0.89	0.02
rs17108817	ADRB2	C	0.44–0.5	0.88	0.02
rs17622933	SOD3	A	0.29–0.3	1.14	0.02
rs357527	PTCH1	A	0.07–0.09	1.24	0.02
rs16865545	SERPINE2	A	0.83–0.85	0.86	0.03
rs3738037	EPHX1	A	0.09–0.1	1.22	0.03
rs1554286	IL10	A	0.19–0.21	1.16	0.03
rs6094238	MMP9	C	0.75–0.77	1.13	0.04
rs1931898	NT5DC1	C	0.95–0.96	0.76	0.06
rs6258	TP53	C	0.97–0.98	1.30	0.08
rs743813	HMOX1	C	0.45–0.48	1.09	0.11
rs12745189	GSTM1	T	0.45–0.47	0.92	0.12
rs20541	IL13	A	0.19–0.21	0.91	0.13
rs1800472	TGFB1	A	0.01–0.03	1.46	0.13
rs9291163	GC	T	0.4–0.42	1.06	0.23
rs7744809	TSPYL4	A	0.37–0.37	0.94	0.24
rs676653	GSTP1	A	0.97–0.98	1.25	0.33

Definition of abbreviations: OR = odds ratio; SNP = single-nucleotide polymorphism.

^*SNPs are the top ranking SNPs in each gene by P value. Some genic intervals overlap, resulting in the same top ranking SNP for different intervals.

^†Allele of reference for calculation of odds ratio.

^‡Range of frequencies of the reference allele in the four study samples.

^§Unadjusted P value for association with chronic obstructive pulmonary disease.