Figure 1.

Type 2 deiodinase gene (DIO2) expression in mouse lung tissues correlates with severity of LPS- and ventilation-induced lung injury (VILI). Expression profiling values (Affymetrix Microarray; Santa Clara, CA) were retrieved from the four datasets described in Materials and Methods and DIO2 expression levels assessed in two preclinical models of acute lung injury (ALI). (A) Box plot of duration-dependent DIO2 expression in LPS-induced lung injury lungs. (B) Box plot of tidal volume–dependent DIO2 expression in VILI lungs. Signal intensities were normalized using the Robust Multi-Array algorithm and expressed as log₂ values.