TABLE 1.

PROHORMONE THYROXINE BLOOD LEVELS IN SPONTANEOUS BREATHING, VENTILATION-INDUCED LUNG INJURY, AND LPS-INDUCED LUNG INJURY MURINE MODELS

	T4 Level (μg/dl)
Treatment	SB Model	VILI Model	LPS Model
CTRL	3.8 ± 05	1.5 ± 0.2*	1.8 ± 0.2†
siCTRL	4.9 ± 0.5	1.9 ± 0.2	1.7 ± 0.3
siDIO2	3.5 ± 0.2	2.9 ± 0.3‡	2.6 ± 0.1§

Definition of abbreviations: CTRL, control; SB, spontaneous breathing; siCTRL, silencing control; siDIO2, silencing type 2 deiodinase; T4, thyroxine; VILI, ventilation-induced lung injury.

T4 level is presented as mean ± SE and analyzed by one-way ANOVA or nonparametric Newman-Keuls test.

^*P < 0.05 for VILI CTRL versus SB (CTRL, siCTRL, and siDIO2).

^†P < 0.05 for LPS CTRL versus SB (CTRL, siCTRL, and siDIO2).

^‡P = 0.041 between VILI siDIO2, VILI CTRL, and VILI siCTRL.

^§P = 0.0039 between LPS siDIO2, LPS CTRL, and LPS siCRTL.