Figure 4.
Concentrations of whole-cell cAMP in murine tracheal epithelial cells exposed to 9.32 ng/ml PAHs for 24 hours. cAMP was measured after treatment with the adenylyl cyclase activator forskolin (2 × 10−5 M) for 15 minutes, to test for adenylyl cyclase function. The data represent cAMP in pmol/mg protein. Control samples were treated with the same concentration of vehicle (16.8% DMSO in complete medium) as the 9.32 ng/ml PAH–treated cells. *P = 0.002, versus vehicle-treated control samples.