Figure 2.

Elevated concentrations of cyclophilin A (CypA) are present during the chronic phase of asthma. Concentrations of CypA, eotaxin, regulated upon activation, normal T-cell expressed and presumably secreted (RANTES), monocyte chemotactic protein (MCP)-1, and MCP-3 were measured in the BAL fluid of mice killed at the time points specified in Figure 1. Measurements were determined via Western blot analysis (CypA), ELISA (eotaxin), or cytometric bead array (RANTES, MCP-1, and MCP-3). Data show the mean ± SEM for concentrations of each chemoattractant in OVA-challenged versus PBS-challenged groups. A Student t test was used to establish statistically significant differences between OVA and PBS data at each time point (n = 4–12 mice per group). **P < 0.005. ***P < 0.0005.