Table 3.
Comparison of Frequency of Severe Hypoglycemia in Published Clinical Trials
| First author/study | ICU | Target glycemic range (mg/dl) | Median glucose (mg/dl) | Glucose <40 mg/dl |
|---|---|---|---|---|
| Van den Berghe6 | Surgical | 80–110 | 103 | 5.1% |
| Van den Berghe5 | Medical | 80–110 | 111 | 18.7% |
| Brunkhorst13 (VISEP) | Combined | 80–110 | 130 | 17% |
| Preiser4 (GLUCONTROL) | Combined | 110 | 9.8% | |
| Finfer3 (NICE-SUGAR) | Combined | 81–108 | 118 | 6.8% |
| Mayo ICU insulin infusion protocol A | Combined | 80–130 | 118.5 | 1.4% |
| Mayo ICU insulin infusion protocol B | Combined | 110–150 | 132 | 0% |