Table 1.
Subject Characteristics and Primary Dataa
| Subject # | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Mean | SEM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | 64 | 34 | 69 | 53 | 22 | 22 | 27 | 51 | 43 | 67 | 45.2 | 5.77 |
| Gender | F | F | M | F | F | F | F | M | F | M | ||
| BMI | 20.1 | 24.0 | 23.7 | 28.0 | 29.3 | 26.5 | 34.5 | 31.5 | 25.5 | 20.0 | 26.31 | 1.480 |
| DM type | T3 | T1 | T3 | T1 | T1 | T1 | T1 | T1 | T1 | T3 | ||
| Duration | 1 | 18 | 13 | 35 | 18 | 8 | 17 | 33 | 27 | 1 | ||
| HbA1c% | 8.1 | 6.2 | 8.4 | 7.3 | 7.4 | 7.6 | 6.0 | 7.1 | 6.5 | 8.5 | 7.31 | 0.340 |
| Day 2 Saline | ||||||||||||
| Avg Glucose | 141.7 | 164.8 | 96.9 | 122.6 | 143.5 | 182.3 | 109.3 | 171.7 | 136.4 | 211.0 | 148.03 | 11.021 |
| G Nadir | 65 | 62 | 54 | 58 | 73 | 40 | 75 | 101 | 71 | 175 | 77.4 | 11.34 |
| Tot Insulin | 25.0 | 53.1 | 47.1 | 27.1 | 50.2 | 71.4 | 87.2 | 53.2 | 52.9 | 14.2 | 48.13 | 6.894 |
| I/G | 0.18 | 0.32 | 0.49 | 0.22 | 0.35 | 0.39 | 0.80 | 0.31 | 0.39 | 0.07 | 0.351 | 0.0624 |
| 1/(I/G) | 5.68 | 3.10 | 2.06 | 4.52 | 2.85 | 2.55 | 1.25 | 3.23 | 2.58 | 14.90 | 4.27 | 1.244 |
| Day 3 Saline | ||||||||||||
| Avg Glucose | 196.5 | 110.6 | 166.4 | 125.2 | 144.7 | 281.2 | 98.8 | 122.0 | 120.6 | 303.4 | 166.91 | 22.800 |
| G Nadir | 62 | 40 | 50 | 56 | 61 | 135 | 19 | 45 | 45 | 230 | 74.3 | 18.74 |
| Tot Insulin | 24.0 | 49.6 | 52.7 | 23.3 | 63.7 | 53.0 | 99.5 | 48.5 | 29.0 | 19.5 | 46.28 | 7.658 |
| I/G | 0.12 | 0.45 | 0.32 | 0.19 | 0.44 | 0.19 | 1.01 | 0.40 | 0.24 | 0.06 | 0.34 | 0.0850 |
| 1/(I/G) | 8.18 | 2.23 | 3.16 | 5.37 | 2.27 | 5.30 | 0.99 | 2.52 | 4.16 | 15.52 | 4.97 | 1.343 |
| Day 2 PP | ||||||||||||
| Avg Glucose | 185.3 | 146.1 | 156.1 | 137.9 | 142.2 | 190.1 | 158.4 | 132.6 | 153.3 | 339.0 | 174.10 | 19.267 |
| G Nadir | 82 | 73 | 40 | 94 | 88 | 80 | 73 | 50 | 51 | 175 | 80.6 | 11.28 |
| Tot Insulin | 25.9 | 30.8 | 30.9 | 20.1 | 34.1 | 60.0 | 98.8 | 39.8 | 37.9 | 19.1 | 39.75 | 7.528 |
| I/G | 0.14 | 0.21 | 0.20 | 0.15 | 0.24 | 0.32 | 0.62 | 0.30 | 0.25 | 0.06 | 0.248 | 0.0485 |
| 1/(I/G) | 7.15 | 4.74 | 5.05 | 6.86 | 4.17 | 3.17 | 1.60 | 3.33 | 4.05 | 17.71 | 5.78 | 1.425 |
| Day 3 PP | ||||||||||||
| Avg Glucose | 254.0 | 111.6 | 145.9 | 120.6 | 110.8 | 178.0 | 138.3 | 207.3 | 122.3 | 316.0 | 170.48 | 21.866 |
| G Nadir | 53 | 61 | 34 | 72 | 87 | 78 | 59 | 49 | 52 | 240 | 78.5 | 17.63 |
| Tot Insulin | 19.9 | 35.4 | 24.6 | 19.8 | 37.1 | 53.1 | 88.2 | 41.5 | 32.5 | 20.2 | 37.23 | 6.628 |
| I/G | 0.08 | 0.32 | 0.17 | 0.16 | 0.34 | 0.30 | 0.64 | 0.20 | 0.27 | 0.06 | 0.253 | 0.0522 |
| 1/(I/G)) | 12.75 | 3.15 | 6.01 | 6.09 | 2.99 | 3.35 | 1.57 | 5.00 | 3.76 | 15.66 | 6.03 | 1.448 |
a
BMI = body mass index; DM =diabetes; T1 =type 1 DM; T3 =type 3c DM; Avg = average; Tot = Total; G nadir = lowest glucose value during 24 h period; Duration = duration of diabetes (yrs); I/G = Total 24 h insulin requirement/average 24 h glucose value; 1/(I/G) = insulin sensitivity index; SEM = standard error of the mean; F = female; M = male; HbA1c = hemoglobin A1c