Table 2. Genotype data of PNPLA3 variant rs738409 in German (n = 128) and Dutch (n = 7) patients with alcoholic liver cirrhosis, German patients with idiopathic and hereditary CP and in German controls.
| Variant | Genotype | Patients | Controls | p-Value | OR |
| ALC | German | ||||
| p.I148M c.444C>G rs738409 | CC | 51/135 (37.8%) | 1135/1950 (58.2%) | <0.0001 | 2.3 (1.6–3.3) |
| GC | 59/135 (43.7%) | 718/1950 (36.8%) | |||
| GG | 25/135 (18.5%) | 97/1950 (5.0%) | |||
| ICP/HP | German | ||||
| CC | 240/414 (58%) | 1135/1950 (58.2%) | n.s. | - | |
| GC | 143/414 (34.5%) | 718/1950 (36.8%) | |||
| GG | 31/414 (7.5%) | 97/1950 (5.0%) |
Percentages are given in brackets. P-values were calculated for these groups in a dominant and recessive model. The p-value represents the result of the dominant model (CC vs. GC+CC). Abbreviations: ALC = alcoholic liver cirrhosis, ICP = idiopathic CP, HCP = hereditary CP, n.s. = not significant.