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. 2012 Jan 20;7(1):e30433. doi: 10.1371/journal.pone.0030433

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Martinaud et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Voxel-based lesion-symptom mapping (VLSM, right panel), comparing the performance of patients with and without a lesion of each voxel, with voxelwise Z statistics corrected for multiple comparisons over the whole brain (threshold: FDR p<0.05). Significant regions are contiguous to the peaks of the corresponding functional areas as identified in normal subjects (red crosshair). Addition of normalized lesions (left panel) for patients with a deficit for words (n = 3; top panel), faces (n = 9; middle panel), and houses (n = 10; bottom panel), minus the lesions of patients with no deficit in the considered category. The regions of maximum overlap are essentially identical to those identified using VLSM.