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Dependence of the apparent cooperativity coefficient (αapp) on subunit instability (KU0=[UF]/[FF]) calculated using Eq. [1] and (a) the intrinsic cooperativity coefficient (αint=1.3) and ratio of melting equilibrium constants constants (φ=1.9) determined for AAC(6′)-Ii at 37°C and (b) hypothetical proteins in which αint=φ=4,16,64,256,1024. The circle in (a) corresponds to the KU0 value obtained for AAC(6′)-Ii at 37°C (0.2).
