FIG. 6.

Effect of CYP and POR inhibitors on AAI-DNA adduct formation catalyzed by hepatic microsomes isolated from CYP1A-humanized and WT mice (Arlt et al., 2011a) pretreated with AAI. Values are given as means ± SD of three parallel incubations (n = 3). RAL, relative adduct labeling. Comparison was performed by t-test analysis; *p < 0.01, different from incubation with NADPH alone. Inhibition is compared with percentage DNA adduct formation in incubations with NADPH as cofactor only. Control, without cofactor. α-NF, α-naphthoflavone. E, ellipticine. FF, furafylline. α-LA, α-lipoic acid. ND, not detected.